Adherence of human oral keratinocytes and gingival fibroblasts to nano-structured titanium surfaces
Identifieur interne : 000A63 ( Main/Exploration ); précédent : 000A62; suivant : 000A64Adherence of human oral keratinocytes and gingival fibroblasts to nano-structured titanium surfaces
Auteurs : Marjan Dorkhan [Suède] ; Tülay Yücel-Lindberg [Suède] ; Jan Hall [Suède] ; Gunnel Svens Ter [Suède] ; Julia R. Davies [Suède]Source :
- BMC Oral Health [ 1472-6831 ] ; 2014.
Abstract
A key element for long-term success of dental implants is integration of the implant surface with the surrounding host tissues. Modification of titanium implant surfaces can enhance osteoblast activity but their effects on soft-tissue cells are unclear. Adherence of human keratinocytes and gingival fibroblasts to control commercially pure titanium (CpTi) and two surfaces prepared by anodic oxidation was therefore investigated. Since implant abutments are exposed to a bacteria-rich environment
The surfaces were characterized using scanning electron microscopy (SEM). The number of adhered cells and binding strength, as well as vitality of fibroblasts and keratinocytes were evaluated using confocal scanning laser microscopy after staining with Live/Dead
SEM analysis showed the two anodically oxidized surfaces to be nano-structured with differing degrees of pore-density. Over 24 hours, both fibroblasts and keratinocytes adhered well to the nano-structured surfaces, although to a somewhat lesser degree than to CpTi (range 42-89% of the levels on CpTi). The strength of keratinocyte adhesion was greater than that of the fibroblasts but no differences in adhesion strength could be observed between the two nano-structured surfaces and the CpTi. The consortium of commensal streptococci markedly reduced keratinocyte adherence on all the surfaces as well as compromising membrane integrity of the adhered cells.
Both the vitality and level of adherence of soft-tissue cells to the nano-structured surfaces was similar to that on CpTi. Co-culture with streptococci reduced the number of keratinocytes on all the surfaces to approximately the same level and caused cell damage, suggesting that commensal bacteria could affect adherence of soft-tissue cells to abutment surfaces
Url:
DOI: 10.1186/1472-6831-14-75
PubMed: 24952379
PubMed Central: 4083866
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adherence of human oral keratinocytes and gingival fibroblasts to nano-structured titanium surfaces</title><author><name sortKey="Dorkhan, Marjan" sort="Dorkhan, Marjan" uniqKey="Dorkhan M" first="Marjan" last="Dorkhan">Marjan Dorkhan</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö SE-205 06, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö SE-205 06</wicri:regionArea><wicri:noRegion>Malmö SE-205 06</wicri:noRegion></affiliation></author><author><name sortKey="Yucel Lindberg, Tulay" sort="Yucel Lindberg, Tulay" uniqKey="Yucel Lindberg T" first="Tülay" last="Yücel-Lindberg">Tülay Yücel-Lindberg</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge SE-141 04, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge SE-141 04</wicri:regionArea><wicri:noRegion>Huddinge SE-141 04</wicri:noRegion></affiliation></author><author><name sortKey="Hall, Jan" sort="Hall, Jan" uniqKey="Hall J" first="Jan" last="Hall">Jan Hall</name><affiliation wicri:level="1"><nlm:aff id="I3">Nobel Biocare AB, Box 5190, Gothenburg SE- 402 26, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Nobel Biocare AB, Box 5190, Gothenburg SE- 402 26</wicri:regionArea><wicri:noRegion>Gothenburg SE- 402 26</wicri:noRegion></affiliation></author><author><name sortKey="Svens Ter, Gunnel" sort="Svens Ter, Gunnel" uniqKey="Svens Ter G" first="Gunnel" last="Svens Ter">Gunnel Svens Ter</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö SE-205 06, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö SE-205 06</wicri:regionArea><wicri:noRegion>Malmö SE-205 06</wicri:noRegion></affiliation></author><author><name sortKey="Davies, Julia R" sort="Davies, Julia R" uniqKey="Davies J" first="Julia R" last="Davies">Julia R. Davies</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö SE-205 06, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö SE-205 06</wicri:regionArea><wicri:noRegion>Malmö SE-205 06</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24952379</idno><idno type="pmc">4083866</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083866</idno><idno type="RBID">PMC:4083866</idno><idno type="doi">10.1186/1472-6831-14-75</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000270</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000270</idno><idno type="wicri:Area/Pmc/Curation">000270</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000270</idno><idno type="wicri:Area/Pmc/Checkpoint">000496</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000496</idno><idno type="wicri:Area/Ncbi/Merge">000E53</idno><idno type="wicri:Area/Ncbi/Curation">000E53</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E53</idno><idno type="wicri:Area/Main/Merge">000A65</idno><idno type="wicri:Area/Main/Curation">000A63</idno><idno type="wicri:Area/Main/Exploration">000A63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Adherence of human oral keratinocytes and gingival fibroblasts to nano-structured titanium surfaces</title><author><name sortKey="Dorkhan, Marjan" sort="Dorkhan, Marjan" uniqKey="Dorkhan M" first="Marjan" last="Dorkhan">Marjan Dorkhan</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö SE-205 06, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö SE-205 06</wicri:regionArea><wicri:noRegion>Malmö SE-205 06</wicri:noRegion></affiliation></author><author><name sortKey="Yucel Lindberg, Tulay" sort="Yucel Lindberg, Tulay" uniqKey="Yucel Lindberg T" first="Tülay" last="Yücel-Lindberg">Tülay Yücel-Lindberg</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge SE-141 04, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge SE-141 04</wicri:regionArea><wicri:noRegion>Huddinge SE-141 04</wicri:noRegion></affiliation></author><author><name sortKey="Hall, Jan" sort="Hall, Jan" uniqKey="Hall J" first="Jan" last="Hall">Jan Hall</name><affiliation wicri:level="1"><nlm:aff id="I3">Nobel Biocare AB, Box 5190, Gothenburg SE- 402 26, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Nobel Biocare AB, Box 5190, Gothenburg SE- 402 26</wicri:regionArea><wicri:noRegion>Gothenburg SE- 402 26</wicri:noRegion></affiliation></author><author><name sortKey="Svens Ter, Gunnel" sort="Svens Ter, Gunnel" uniqKey="Svens Ter G" first="Gunnel" last="Svens Ter">Gunnel Svens Ter</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö SE-205 06, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö SE-205 06</wicri:regionArea><wicri:noRegion>Malmö SE-205 06</wicri:noRegion></affiliation></author><author><name sortKey="Davies, Julia R" sort="Davies, Julia R" uniqKey="Davies J" first="Julia R" last="Davies">Julia R. Davies</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö SE-205 06, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö SE-205 06</wicri:regionArea><wicri:noRegion>Malmö SE-205 06</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Oral Health</title><idno type="eISSN">1472-6831</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>A key element for long-term success of dental implants is integration of the implant surface with the surrounding host tissues. Modification of titanium implant surfaces can enhance osteoblast activity but their effects on soft-tissue cells are unclear. Adherence of human keratinocytes and gingival fibroblasts to control commercially pure titanium (CpTi) and two surfaces prepared by anodic oxidation was therefore investigated. Since implant abutments are exposed to a bacteria-rich environment <italic>in vivo</italic>, the effect of oral bacteria on keratinocyte adhesion was also evaluated.</p></sec><sec><title>Methods</title><p>The surfaces were characterized using scanning electron microscopy (SEM). The number of adhered cells and binding strength, as well as vitality of fibroblasts and keratinocytes were evaluated using confocal scanning laser microscopy after staining with Live/Dead <italic>Bac</italic>light. To evaluate the effect of bacteria on adherence and vitality, keratinocytes were co-cultured with a four-species streptococcal consortium.</p></sec><sec><title>Results</title><p>SEM analysis showed the two anodically oxidized surfaces to be nano-structured with differing degrees of pore-density. Over 24 hours, both fibroblasts and keratinocytes adhered well to the nano-structured surfaces, although to a somewhat lesser degree than to CpTi (range 42-89% of the levels on CpTi). The strength of keratinocyte adhesion was greater than that of the fibroblasts but no differences in adhesion strength could be observed between the two nano-structured surfaces and the CpTi. The consortium of commensal streptococci markedly reduced keratinocyte adherence on all the surfaces as well as compromising membrane integrity of the adhered cells.</p></sec><sec><title>Conclusion</title><p>Both the vitality and level of adherence of soft-tissue cells to the nano-structured surfaces was similar to that on CpTi. Co-culture with streptococci reduced the number of keratinocytes on all the surfaces to approximately the same level and caused cell damage, suggesting that commensal bacteria could affect adherence of soft-tissue cells to abutment surfaces <italic>in vivo</italic>.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aas, Ja" uniqKey="Aas J">JA Aas</name></author><author><name sortKey="Paster, Bj" uniqKey="Paster B">BJ Paster</name></author><author><name sortKey="Stokes, Ln" uniqKey="Stokes L">LN Stokes</name></author><author><name sortKey="Olsen, I" uniqKey="Olsen I">I Olsen</name></author><author><name sortKey="Dewhirst, Fe" uniqKey="Dewhirst F">FE Dewhirst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Busscher, H" uniqKey="Busscher H">H Busscher</name></author><author><name sortKey="Van Der Mei, H" uniqKey="Van Der Mei H">H van der Mei</name></author><author><name sortKey="Subbiahdoss, G" 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Rundcranz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moon, Is" uniqKey="Moon I">IS Moon</name></author><author><name sortKey="Berglundh, T" uniqKey="Berglundh T">T Berglundh</name></author><author><name sortKey="Abrahamsson, I" uniqKey="Abrahamsson I">I Abrahamsson</name></author><author><name sortKey="Linder, E" uniqKey="Linder E">E Linder</name></author><author><name sortKey="Lindhe, J" uniqKey="Lindhe J">J Lindhe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Kaplan, Jb" uniqKey="Kaplan J">JB Kaplan</name></author><author><name sortKey="Lee, Wy" uniqKey="Lee W">WY Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subbiahdoss, G" uniqKey="Subbiahdoss G">G Subbiahdoss</name></author><author><name sortKey="Kuijer, R" uniqKey="Kuijer R">R Kuijer</name></author><author><name sortKey="Busscher, Hj" uniqKey="Busscher H">HJ Busscher</name></author><author><name sortKey="Van Der Mei, Hc" uniqKey="Van Der Mei H">HC van der Mei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carlsson, J" uniqKey="Carlsson J">J Carlsson</name></author><author><name sortKey="Griffith, C" uniqKey="Griffith C">C Griffith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drucker, D" uniqKey="Drucker D">D Drucker</name></author><author><name sortKey="Melville, T" uniqKey="Melville T">T Melville</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niebuhr, M" uniqKey="Niebuhr M">M Niebuhr</name></author><author><name sortKey="Baumert, K" uniqKey="Baumert K">K Baumert</name></author><author><name sortKey="Werfel, T" uniqKey="Werfel T">T Werfel</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Dorkhan, Marjan" sort="Dorkhan, Marjan" uniqKey="Dorkhan M" first="Marjan" last="Dorkhan">Marjan Dorkhan</name></noRegion><name sortKey="Davies, Julia R" sort="Davies, Julia R" uniqKey="Davies J" first="Julia R" last="Davies">Julia R. Davies</name><name sortKey="Hall, Jan" sort="Hall, Jan" uniqKey="Hall J" first="Jan" last="Hall">Jan Hall</name><name sortKey="Svens Ter, Gunnel" sort="Svens Ter, Gunnel" uniqKey="Svens Ter G" first="Gunnel" last="Svens Ter">Gunnel Svens Ter</name><name sortKey="Yucel Lindberg, Tulay" sort="Yucel Lindberg, Tulay" uniqKey="Yucel Lindberg T" first="Tülay" last="Yücel-Lindberg">Tülay Yücel-Lindberg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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